Leveraging South African HIV research to define SARS-CoV-2 immunity triggered by sequential variants of concernArticle Published on 2022-09-012022-11-15 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome African antigenic assays B cell cause Combination coronavirus coronavirus disease COVID-19 cross-reactive cross-reactive antibodies driving elicited Epidemic Frequency genomic highlight HIV HIV vaccine hybrid immunity. immune response Immunity immunogenic immunological immunology Infection mutated variants pandemic platform population immunity Prevent Region Research respiratory viruses respond response responses SARS-CoV-2 SARS-CoV-2 immunity shown South Surveillance the SARS-CoV-2 to define triggered vaccination Vaccine variants variants of concern virus VoC [DOI] 10.1111/imr.13086 PMC 바로가기
SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection감염성이 감소하고 BNT162B2 백신에 대한 감도가 다양한 SARS-COV-2 변이체가 감염 과정에서 개발됩니다.Clinical Trial Published on 2022-01-122022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, 변종, 임상, 치료기술, 치료법, [키워드] addition Affect Analysis analyzed Anti-spike Antibody neutralization antibody neutralization activity Author BNT162b2 BNT162b2 vaccine circulating convalescent plasma Course COVID-19 vaccine COVID-19 vaccines demonstrated elicit employment Evolution Frequency highlight Host human host human population impair in-depth analysis increase in individual infected individual infected individuals Infection infectivity capacity intra-host SARS-CoV-2 variant intra-host SARS-CoV-2 variants Intra-host variant intra-host variants L1197I mutation landscape less low frequencies mRNA mRNA-based mutated mutated variant mutated variants N gene N genes natural infection neutralization Neutralizing antibodies nose-throat swab nose-throat swabs pandemic plasma plasma neutralization activity platform Point mutation potential circulating variants Protective Quasispecies quasispecy raised reduced respiratory Respiratory system S gene S2 subunit SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 intra-host variability SARS-CoV-2 intra-host variant SARS-CoV-2 intra-host variants SARS-CoV-2 mutagenesis SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing Sequencing database Sequencing databases single-genome sequencing Spike protein Spike proteins spike variant Spread swab sample swab samples the SARS-CoV-2 the spike protein vaccinated individuals vaccination rate variant variants variants of concern [DOI] 10.1371/journal.ppat.1010242 PMC 바로가기 [Article Type] Clinical Trial
Structural and Dynamical Differences in the Spike Protein RBD in the SARS-CoV-2 Variants B.1.1.7 and B.1.351SARS-CoV-2 변이체 B.1.1.7 및 B.1.351에서 스파이크 단백질 RBD의 구조 및 동적 차이Article Published on 2021-07-082022-09-11 Journal: The journal of physical chemistry. B [Category] SARS, 변종, [키워드] 501Y.V2 ACE2 B.1.1.7 B.1.351 B.1.351 variant complex contributing to difference Factor flexible host receptor hydrogen Hydrogen bond hydrogen bond network Interaction investigated molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutated variants Mutation mutations new strain Novel coronavirus pandemic performed RBD RBD-ACE2 Receptor binding domain residue responsible SARS-CoV-2 Spike protein stability stable complex the RBD the SARS-CoV-2 the Spike transmissivity Vaccine variant variants virus virus spike protein wild-type [DOI] 10.1021/acs.jpcb.1c01626 PMC 바로가기 [Article Type] Article
The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccinesSARS-CoV2[알파, 베타, 감마, 델타 및 람다]의 스파이크 돌연변이 변이체가 소단위 재조합 백신의 효능에 미치는 영향Review Published on 2021-07-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 변종, 진단, [키워드] (alpha (Alpha) (Beta ACE2 Alpha alpha and delta variants Alpha variant analysis angiotensin Angiotensin-converting enzyme antibody Antigen B.1.1.7 B.1.351 B.1.617 Beta bind binding COVID-19 Delta delta variant described Efficacy elicited focus Gamma greater host cell human infection humans immune response immunization infection process Invasion Lambda mutated variant mutated variants Mutation neutralize Prevent Protein RBD receptor Receptor binding domain recombinant vaccine recombinant vaccines reported robust SARS-CoV-2 SARS-CoV-2 variants SARS-CoV2 specific antibodies specific antibody spike Spike protein subunit subunit protein vaccine Subunit vaccine subunit vaccines Vaccine Vaccine development vaccine efficacy variant Variant. variants variants of SARS-CoV-2 virus [DOI] 10.1016/j.bjid.2021.101606 PMC 바로가기 [Article Type] Review
A Summary of the SARS-CoV-2 Vaccines and Technologies Available or under DevelopmentReview Published on 2021-06-222022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] age clinical trial clinical trials country COVID-19 COVID-19 pandemic develop development DNA vaccines dosage Effect effective Factor humans immune response inactivated viruses include initiated Live attenuated vaccines Messenger RNA Modification mounted mRNA mutated variant mutated variants outcomes parameters Phase 3 Protein protocol researcher SARS-CoV-2 Seven Side effects storage conditions subunits technology the SARS-CoV-2 Vaccine vaccinee Vaccines vectors viral-like particles [DOI] 10.3390/pathogens10070788 PMC 바로가기 [Article Type] Review
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus InfectionSTING 신호 전달 경로의 활성화는 인간 코로나바이러스 감염을 효과적으로 차단합니다Article Published on 2021-05-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] Activation addition Antiviral antiviral therapeutics antiviral therapy block coronavirus coronavirus Coronavirus infection coronavirus strain coronavirus. COVID-19 COVID-19 pandemic Defense develop downstream effective examined greater HCoV HCoV-OC43 Health highlight Host host defense Human Human coronavirus human coronavirus OC43 identify IFNs Infection inhibit innate immune interferons IRF3 mutated variants novel OC43 Other other coronaviruses Outbreaks pathogenic coronavirus pathogenic coronaviruses pathway Pathways potential therapeutic target public health SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathway Spread stimulate STING type I interferon type I interferons [DOI] 10.1128/JVI.00490-21 PMC 바로가기 [Article Type] Article